Esophagus برای بزرگنمایی عکسها کلیک را روی ان نگه دارید Figure 13.1 Types of tracheoesophageal anomalies and their relative frequencies. (Adapted from Holder TM, Ashcraft KW. Esophageal atresia and tracheoesophageal fistula. Ann Thorac Surg. 1970;9:445-467.) Figure 13.2 Heterotopic gastric mucosa in the esophagus (cervical inlet patch) Figure 13.3 Heterotopic pancreas at the gastroesophageal junction, mainly represented by islets of Langerhans Figure 13.4 A and B, Outer aspect and inner surface of Zenker diverticulum Figure 13.5 Esophageal cyst lined by ciliated columnar epithelium Figure 13.6 Myenteric plexus in achalasia with scattered lymphocytes and no residual ganglion cells Figure 13.7 Herpes Simplex Esophagitis. Several intranuclear eosinophilic inclusions are seen in the squamous mucosa Figure 13.8 A, CMV inclusions in a patient with Barrett esophagus. B, CMV immunostain showing rare immunopositive cells Figure 13.9 Esophageal Candidiasis. Pseudohyphae are seen within the squamous mucosa Figure 13.10 Eosinophilic Esophagitis. A, There is a marked increase in the number of intraepithelial eosinophils with a surface-heavy infiltrate. B, Eosinophilic microabscesses are characteristic Figure 13.11 Characteristic histologic appearance of so-called sloughing esophagitis Figure 13.12 Gross Appearance of a Severe Case of Reflux Esopha- gitis. Marked hyperemia with focal hemorrhage is present in the area of reflux Figure 13.13 Gastroesophageal reflux disease with marked squamous hyperplasia and basal cell hyperplasia. Scattered intraepithelial inflammatory cells are seen Figure 13.14 A, Barrett esophagus with scattered goblet cells. B, Alcian blue stain at pH 2.5 highlighting the acid mucin-containing goblet cells Figure 13.15 A, Barrett esophagus negative for dysplasia. B, Barrett esophagus with mild chronic inflammation and reactive glandular atypia, negative for dysplasia. C, Barrett esophagus with epithelial alterations indefinite for dysplasia. D, Barrett esophagus with low-grade dysplasia, intestinal type. E, Barrett esophagus with high-grade dysplasia, intestinal type. F, Intramucosal adenocarcinoma with infiltration of glands into the lamina propria Figure 13.16 Various Gross Appearances of Esophageal Squamous Cell Carcinoma. A, Cakelike exophytic mass. B, Circumferential constricting lesion. C, Elevated round nodule with central ulceration. D, Widely invasive lesion with deep ulceration Figure 13.17 Low-power view of an invasive moderately differentiated squamous cell carcinoma of the esophagus Figure 13.18 Gross appearance of sarcomatoid carcinoma of the esophagus. The tumor has a characteristic large size and polypoid shape Figure 13.19 A, Pleomorphic (sarcomatoid) carcinoma of the esophagus. B, Strong cytokeratin 5/6 immunoreactivity is characteristic. C, There is also strong nuclear expression of p63 Figure 13.20 Sarcomatoid carcinoma of the esophagus. In this case, the carcinomatous component has a basaloid appearance Figure 13.21 A, Basaloid squamous cell carcinoma with peripheral nuclear palisading. B, Strong p63 nuclear immunoreactivity is expected in this variant of squamous cell carcinoma Figure 13.22 Gross Appearance of an Esophageal Leiomyoma. The tumor is sharply circumscribed and has a white color and elastic consistency Figure 13.23 Esophageal leiomyoma with bland-appearing, densely eosinophilic spindle cells Figure 13.24 Esophageal Leiomyosarcoma. The cells show nuclear hyperchromasia and pleomorphism Figure 13.25 Extremely rare gastrointestinal stromal tumor of the esophagus. (Courtesy of Dr. Fabio Facchetti, Brescia, Italy.) Figure 13.26 Low-power (A) and high-power (B) views of an esophageal squamous papilloma Figure 13.27 A, Esophageal granular cell tumor with nests of ovoid cells with granular cytoplasm. B, Strong S-100 protein staining in esophageal granular cell tumor Figure 13.28 Malignant Melanoma of Esophagus. The tumor has a characteristic polypoid appearance and is partially ulcerated. The dark color is the combined result of melanin deposition and hemorrhage within the tumor Figure 13.29 Primary Malignant Melanoma of the Esophagus. There is a prominent intraepithelial component with the formation of large tumor nests
